[10], Diethylene glycol has moderate acute toxicity in animal experiments. [60] The world outcry made Chinese officials ban the practice of using diethylene glycol in toothpaste. An unmitigated tragedy", "Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Siegfried Rebsdat and Dieter Mayer "Ethylene Glycol" in Ullmann’s Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, Weinheim. 121; Ethylne glycol butyl ether; Ethylene glycol monobutyl ether; Glycol butyl ether; Monobutyl glycol ether; 3-oxa-1-heptanol; EPA Pesticide Code: 011501 Depending on the conditions, varying amounts of DEG and related glycols are produced. During September 1986, the Ministry of Public Works started testing a mixture of wine with salt to melt hazardous ice during winter. diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO 2. Doctors prescribed glycerine for its osmotic diuretic effect, but patients started to develop kidney failure. Fourteen patients received hemodialysis, but the treatment failed. Features. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. [39] A New York Times reporter tried to obtain a comment from CNSC Fortune Way at the CPhI worldwide (the world’s largest annual pharmaceutical convention) held in Milan, Italy, during 2007, but their representatives refused to comment. The CDC employed modern laboratory equipment to analyze the samples and confirm the results: the samples contained approximately 8% v/v DEG. For late diagnosis where ethanol or fomepizole is ineffective, because DEG has already been metabolized, hemodialysis becomes the only treatment available. Bogdanich, W. "Toxic Toothpaste Made in China Is Found in U.S. ". At the request of the United States, the State Food and Drug Administration of China investigated Taixing Glycerine Factory and CNSC Fortune Way, but the agency concluded it is not under their jurisdiction because the factory is not certified to make medicine. Once he was inside, there was nothing to do: the plant had already been shut down. In July 1996, the American Embassy in China contacted Sinochem and requested a list of Chinese glycerin makers, but the company refused to reveal the names. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. DEGEE. Ethylene Glycol Monobutyl Ether is chemically known as a Butyl Glycol, 1-n-Butoxy-2-hydroxyethane, n-butyl (2-hydroxyethyl) ether. Date: 27 January 2011: Source: Own work: Author: MiPe: Licensing . Authorities warn against using some toothpastes, Taste of Raspberries, Taste of Death – The 1937 Elixir Sulfanilamide Incident, "Wallace Reveals How Federal Agents Traced Elixir to Halt Fatalities", "Medication-associated diethylene glycol mass poisoning: A review and discussion on the origin of contamination", "Popular Wines found to hold toxic chemical. English: Structure of Diethylene glycol monobutyl ether acetate. [70] The investigation revealed that DEG had been used as a coolant for the brewery equipment, in what should have been a closed circuit, but an undetected leak in the system contaminated some batches of beer. Reference: 1. Once verifying that he was fine, he shipped it to Qiquihar No. The industry generally operates to maximize MEG production. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Chemical Nomenclature. The product was recalled and after an investigation, the Drug Controller General of India, VG Somani, said at India Pharma 2020, that the GMP was not followed, and negligence was found during the production process itself. The symptoms seemed to match with Guillain–Barré syndrome, but these patients were also losing their ability to urinate, a symptom not related to Guillain–Barré. 0 references. [3] It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. [42], In August 2009, the Supreme Court decided to send the diethylene glycol file to the Public Ministry for an extension. [3], The physical properties of diethylene glycol make it an excellent counterfeit for pharmaceutical-grade glycerine (also called glycerol) or propylene glycol, and has caused many deaths in different countries. Records also revealed that to fool buyers, Wang falsified his license and laboratory analysis reports. diethylene glycol monobutyl ether (English) retrieved. UNII. The regional drug controller authorities after investigation found out that a faulty batch of the Coldbest PC cough syrup contained 34.97% of diethylene glycol, which resulted in poisoning and subsequent renal failures. 14th ed. Later on, HEAA leaves the liver through the bloodstream, being partially filtered in the kidneys for elimination. * * It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. [1][7], The symptoms of poisoning typically occur in three characteristic intervals:[1], Fomepizole or ethanol should be quickly administered to prevent diethylene glycol being metabolized to the compound or compounds that cause the real damage.[1]. Jean-Claude Bradley Open Melting Point Dataset, NFPA 704: Standard System for the Identification of the Hazards of Materials for Emergency Response, InChI=1S/C8H18O3/c1-2-3-5-10-7-8-11-6-4-9/h9H,2-8H2,1H3, Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard, splash10-006t-9000000000-9b5ce4bf5bfa84239e88, splash10-03di-1900000000-8aef03e0bb456b96d1a4, splash10-03di-0900000000-3ac8a328666dee650638, splash10-0a4j-9000000000-44b0731c3639435643fb, https://www.wikidata.org/w/index.php?title=Q1018210&oldid=1314798026, Creative Commons Attribution-ShareAlike License. The agency also identified urinary DEG as a biomarker for DEG exposures. AICS Chemical ID. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. CARBITOL Solvent. [29] The United States Food and Drug Administration also issued an Industry Guidance Document “intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG)” and recommended appropriate testing procedures for the use of glycerin. In fact, Rasfer received the product from CNSC Fortune Way, which in turn bought it from the Taixing Glycerine Factory. Diethylene glycol is used in the manufacture of saturated and unsaturated polyester resins, polyurethanes, and plasticizers. What began as a local alert revealed a global problem in more than 30 countries and involving more than thirty brands. Wang Guiping discovered how easy it was to enter China’s pharmaceutical supply business and earn extra money. The children later developed kidney failure and died. Packaging 1, 4 L in poly bottle 18 L in steel drum Legal Information Product of Dow Chemical Promotes uniform dispersion; translucent to clear. Description. Dermal absorption is very low, unless it is administered on broken or damaged skin. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Industry Circular No. They also arrested 12 people in connection with the incident. With the available technology of the era, the CDC determined the glycerin used in the syrup preparation was contaminated with approximately 24% DEG. In April 2006, the Guangdong Province Hospital of Guangzhou began administering Amillarisin A to their patients. Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. This event caused the death of five patients.[3][21][22]. , there was nothing to do: the plant had already been metabolized hemodialysis. 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